From the east: Hwy. 82 West to Greenwood, cross the Yazoo River, pass the intersection with Park Avenue, Museum is on the right on the frontage road.
From the west: Hwy 82 East to Greenwood, pass Wal-Mart, Museum is on the left 1/3 mile down, on the frontage road.
From the south: I-55 or US 49 North to Highway 82, follow directions from the east.
From the north: Hwy. 7 South from Grenada to Hwy. 82, follow direction from the east. Hwy. 49 South from Clarksdale to Hwy. 82, follow directions from the west